Measurement of Blood Thiamine Metabolites for Alzheimer's Disease Diagnosis
نویسندگان
چکیده
منابع مشابه
Measurement of Blood Thiamine Metabolites for Alzheimer's Disease Diagnosis
BACKGROUND Brain glucose hypometabolism is an invariant feature and has significant diagnostic value for Alzheimer's disease. Thiamine diphosphate (TDP) is a critical coenzyme for glucose metabolism and significantly reduced in brain and blood samples of patients with Alzheimer's disease (AD). AIMS To explore the diagnostic value of the measurement of blood thiamine metabolites for AD. METH...
متن کاملDiagnostic value of blood thiamine metabolites in Alzheimer’s disease examined by 11C-PiB PET scanning
AIM We evaluated the diagnostic value of blood thiamine metabolites for Alzheimer's disease (AD) by using positron emission tomography with 11C-Pittsburgh compound B (11C-PiB PET) scanning. METHODS Thirty-eight clinically diagnosed AD patients were voluntarily recruited. Blood thiamine metabolites were measured by high-performance liquid chromatography. All the patients received 11C-PiB PET s...
متن کاملFrom heterogeneous patient measurements towards earlier diagnosis in Alzheimers disease
European funded project PredictAD has developed a decision support tool for objective diagnostics of Alzheimer’s disease. The tool compares measurements of a patient to measurements of other persons available in large databases and provides a simple index about the severity of the disease. The project has shown that the tool improves the accuracy of diagnosis and clinicians’ confidence about th...
متن کاملComparison of microscopy and blood-PCR for the diagnosis of clinical Johne’s disease in domestic ruminants
Microscopy as “field based test” was compared with IS900 blood PCR for the diagnosis and estimationof prevalence of Mycobacterium avium subspecies paratuberculosis (MAP) in domestic livestock withclinical Johne’s disease (JD). Of 252 animals screened, 39.3 and 13.1% were positive by faecal microscopyand blood PCR, respectively. Proportional agreement between “microscopy” and blood PCR was subst...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: EBioMedicine
سال: 2016
ISSN: 2352-3964
DOI: 10.1016/j.ebiom.2015.11.039